In a world parallel to ours, there exists a science called alchemy. Alchemists are able to perform special abilities and manipulate objects to their use. But theuniversal truth of alchemy is "in order to gain something, one must give something of equivalent value." The main character is a famous alchemist named Edward Elric, who lost his right arm and little brother's body, Alphonse, in an accident. However, Edward manages to seal his brother's soul in a large piece of armor suit at the cost of giving up his left leg. Now the two brothers must embark on a journey to find a mysterious power amplifier which can reduce the cost to manipulate objects greatly and to get back Al's body and Ed's limbs.